gene therapy
Petroleum industry
Polymer Chemistry
Highlights
Rring-opening polymerization for constructing multicyclic polymers
Cyclic polymers have a number of unique physical properties compared with those of their linear counterparts. However, the methods for the synthesis of cyclic polymers are very limited, and some multicyclic polymers are still not accessible now. Here, we found that the five˗membered cyclic structure and electron withdrawing groups make methylene in rhodanine highly active to aldehyde via highly efficient Knoevenagel reaction
The synthesis of polymers with on-demand sequence structures is very important not only for academic researchers but also for industry.. Here we report a dually switchable and controlled interconvertible polymerization system; in this system, two distinct orthogonal polymerizations can be selectively switched ON/OFF independent of each other and they can be interconverted promptly and quantitatively according to external stimuli.
Synthesis of polymers with on-demand sequence structures via dually switchable and interconvertible polymerizations
High DNA-Binding Affinity and Gene-Transfection Efficacy of Bioreducible Cationic Nanomicelles with a Fluorinated Core
During the last two decades, cationic polymers have become one of the most promising synthetic vectors for gene transfection. However, the weak interactions formed between DNA and cationic polymers result in low transfection efficacy. Furthermore, the polyplexes formed between cationic polymers and DNA generally exhibit poor stability and toxicity because of the large excess of cationic polymer typically required for complete DNA condensation. Herein, we report the preparation of a novel class of bioreducible cationic nanomicelles by the use of disulfide bonds to connect the cationic shell to the fluorocarbon core.
News
2022.06:Warmly welcome Professor Long-Hai Wang to join the research group.
2022.08.03:Academic Report of Professor Min-Qiang Zhu of Huazhong University of Science and Technology.
2022.08.03:Academic Report of Professor Jun-bing Fan of Southern Medical University
2022.09.23:Academic Report of Professor Chuan-liang Feng of Southern Medical University
2022.09.30:Academic Report of Professor Yue Li of Laboratory of Materials Physics, Institute of Solid State Physics, CAS
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