Our Laboratory
We are an experimental research group in biomaterials science and polymerization. Using the controled polymerization to construct the functional biomaterialsm, and investigeting the applications in cancer treatment, gene therapy, antibacterial therapy.
Research Interests
1. Design and construct the nanomedicine in cancer treatment.
2. Gene therapy based on non-viral gene vectors.
3. Functional nanoparticle in biomaterials.
4. Controllable synthesis of degradable polymers.
Highlights
Rring-opening polymerization for constructing multicyclic polymers
Cyclic polymers have a number of unique physical properties compared with those of their linear counterparts. However, the methods for the synthesis of cyclic polymers are very limited, and some multicyclic polymers are still not accessible now. Here, we found that the five˗membered cyclic structure and electron withdrawing groups make methylene in rhodanine highly active to aldehyde via highly efficient Knoevenagel reaction
The synthesis of polymers with on-demand sequence structures is very important not only for academic researchers but also for industry.. Here we report a dually switchable and controlled interconvertible polymerization system; in this system, two distinct orthogonal polymerizations can be selectively switched ON/OFF independent of each other and they can be interconverted promptly and quantitatively according to external stimuli.
Synthesis of polymers with on-demand sequence structures via dually switchable and interconvertible polymerizations
High DNA-Binding Affinity and Gene-Transfection Efficacy of Bioreducible Cationic Nanomicelles with a Fluorinated Core
During the last two decades, cationic polymers have become one of the most promising synthetic vectors for gene transfection. However, the weak interactions formed between DNA and cationic polymers result in low transfection efficacy. Furthermore, the polyplexes formed between cationic polymers and DNA generally exhibit poor stability and toxicity because of the large excess of cationic polymer typically required for complete DNA condensation. Herein, we report the preparation of a novel class of bioreducible cationic nanomicelles by the use of disulfide bonds to connect the cationic shell to the fluorocarbon core.
News
2022.06:Warmly welcome Professor Long-Hai Wang to join the research group.
2022.05: Congratulations to Wu Bin and Jamshid on their successful defense of their doctoral thesis.
2022.03 : Activity of the research group: visit to the martyrs' cemetery.
2022.08.03:Academic Report of Professor Min-Qiang Zhu of Huazhong University of Science and Technology.
2022.08.03:Academic Report of Professor Jun-bing Fan of Southern Medical University
Ye-Zi You Lab
Address:No. 96 Jinzhai Road, Hefei City, Anhui Province China
Postcode: 230026 | Tel: (86) 551 63607235 | E-mail: yzyou@ustc.edu.cn
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